Abatacept (Orencia) - All What You Need to Know. What is it, How to Take, and Side Effects

Brand Names
Orencia

Other Names
Immunosuppressants
Monoclonal Antibodies
biologics

How does this medicine work?
Abatacept is used alone or together with other medicines to reduce the signs and symptoms of arthritis, such as joint swelling, pain, and fatigue by inhibiting T cell (T lymphocyte) activation.

What is this drug used for?
  • Rheumatoid Arthritis (RA)
  • Juvenile Idiopathic Arthritis
  • Psoriatic Arthritis (PsA)

Do I need a prescription for Abatacept?
Yes.

How is this drug best taken?
Abatacept may be given as an injection under your skin, similar to insulin injections. It may also be administered to you as an infusion. The infusion is given intravenously (through a needle placed in a vein) at 0, 2, and 4 weeks, then monthly thereafter in your doctor’s office or at an infusion center. The dosage is adjusted according to the patient’s weight. It takes 30-60 minutes to receive the whole infusion.

The injectable form of abatacept is injected under the skin at home once a week. It can be administered by the patient or another member of the home. Studies have shown this formulation to be as safe and effective as the infusion.

What are the most common side effects?
The most common side effects reported were those associated with headaches, common colds, sore throat, and nausea. The most important side effect is the risk of developing a serious infection, including pneumonia, tuberculosis, and others (infusion-related reactions and hypersensitivity reactions).

What do I do if I miss a dose?
Call your doctor to find out what to do next.

When should I call the clinic?
  • chest pain
  • irregular heartbeat
  • swelling in face, lips, or throat
  • trouble swallowing
  • signs of infection:
    -This includes minor infections
    - cough, cold, sore throat
    - fever or chills
  • signs of allergic reaction:
    - flushing
    - dizziness
    - fainting
    - rash or hives
    - wheezing
    - trouble breathing - call 911

These highlights do not include all the information needed to use Abatacept. Ask your doctor if you have questions.