Tocilizumab (Actemra) Education Materials: Uses, Side Effects, and Interactions.

Brand Names
Actemra

Other Names
Immunosuppressants
Monoclonal Antibodies
biologics

How does this medicine work?
In rheumatoid arthritis too much of a protein called IL-6 may be produced in the body. This can lead to tiredness, anaemia, inflammation and damage to bones, cartilage and soft tissues. Tocilizumab blocks the action of IL-6, reducing these effects. It can modify the disease over a longer period. It may be 2–12 weeks before you notice an improvement, often sooner.

What is this drug used for?
  • Rheumatoid arthritis.
  • Juvenile idiopathic arthritis.
  • Giant cell arteritis (GCA)

Do I need a prescription for Tocilizumab?
Yes.

How is this drug best taken?
Tocilizumab may be given:
  • either through a drip into a vein (an intravenous infusion) which takes about an hour once every four weeks
  • or as an injection under the skin (a subcutaneous injection) once a week.
What are the most common side effects?
Tocilizumab can lower the ability of your immune system to fight infections. Allergic reactions to tocilizumab can occur, which can include symptoms such as fever and chills, but these are rare. Tocilizumab has been associated with increased cholesterol levels in some patients, and should be periodically monitored. The most common side effects of Tocilizumab include: upper respiratory tract infections (common cold, sinus infections), headache, and increased blood pressure (hypertension).

What do I do if I miss a dose?
Call your doctor to find out what to do next.

When should I call the clinic?
  • chest pain
  • irregular heartbeat
  • swelling in face, lips, or throat
  • trouble swallowing
  • signs of infection:
    -This includes minor infections
    - cough, cold, sore throat
    - fever or chills
  • signs of allergic reaction:
    - flushing
    - dizziness
    - fainting
    - rash or hives
    - wheezing
    - trouble breathing - call 911

These highlights do not include all the information needed to use Tocilizumab. Ask your doctor if you have questions.